Fig. 4.

Clinical variables and outcome. a) Forest plots representing hazard ratios and confidence intervals for univariate (blue) and multivariate (grey). Cox models for disease-free survival estimated using clinical variables in the training cohort. ∗: Log-rank test p-value ≤0.05. Risk stage variable was estimated using time-dependent coefficient. Coefficients for tt1 (Risk stage) and tt2 (Risk stage) describe time varying effect of risk stage evaluated between 0 and 22 months, and 22 and 60 months, respectively. Kaplan–Meier curves with patients stratified according to the clinical model for disease-free survival in the b) training, c) internal validation and d) external validation cohort. Hazard ratio and log-rank test p-value were shown when proportional hazards assumption was verified otherwise the RMST measure and p-value were shown.