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. 2024 Apr 29;11(26):2308892. doi: 10.1002/advs.202308892

Figure 6.

Figure 6

Divergent densities of the tertiary lymphoid structure (TLS) in different anatomical sites of LUAD. A) Representative patch diagrams of the TLS‐like structure in the four anatomical sites of LUAD. Each color represents one TLS‐like structure. B) The frequencies of each cell cluster identified from IMC images in the TLS‐like structures in each sample. C) The frequencies of T‐cell and B‐cell‐related clusters identified from IMC images in the TLS‐like structures in each sample. D) The presence of TLS identified by the H&E staining and multiplex immunofluorescence (mIF) staining of CD3, CD8, CD20, and CD21. E) Densities of TLS in different anatomical sites of LUAD from the validation cohort. The P value was estimated by the Wilcoxon rank‐sum test. F) The expression levels of exhausted markers on T cells in TLS‐like structures in each anatomic site of LUAD.