Table 1.

A comparative review of biochemical and inflammatory parameters and non-invasive scores between groups defined by ultrasound NAFLD severity grades

Characteristics	Grade 1 of liver steatosis (n = 89)	Grade 2 of liver steatosis (n = 55)	Grade 3 of liver steatosis (n = 40)	F	P
BMI (kg/m2 )	25.61 ± 2.13	26.50 ± 1.83	27.67 ± 1.62ab	6.049	0.003
WC (cm)	90.43 ± 7.75	102.12 ± 7.66	102.21 ± 8.01ab	94.200	0.000
HbA1c (%)	7.55 ± 0.80	7.47 ± 0.53	7.47 ± 0.53	0.225	0.799
C-peptide (ng/ml)	2.43 ± 0.58	4.13 ± 1.20	4.99 ± 0.61ab	48.9	0.000
FPG (mmol/l)	7.67 ± 1.23	6.41 ± 1.00	7.40 ± 0.63ab	4.49	0.009
Platelet count(*109 /L)	132 ± 43	144 ± 29	138 ± 38	7.431	0.099
ALT (U/L)	24.70 ± 10.36	32.33 ± 11.82	54.55 ± 4.42ab	18.05	0.000
AST (U/L)	20.91 ± 3.61	19.05 ± 2.90	31.20 ± 3.64	0.834	0.438
γGT (U/L)	22 ± 13	69 ± 20	122 ± 31	5.833	0.001
25(OH)D (ng/ml)	35.69 ± 6.10	26.70 ± 3.10a	14.53 ± 6.26ab	7.17	0.001
PTH (pg/ml)	37.67 ± 11.23	36.41 ± 14.00	37.40 ± 10.63	4.99	0.339
TC (mmol/l)	6.63 ± 1.39	7.67 ± 1.23	7.67 ± 1.23ab	4.208	0.018
TG (mmol/l)	2.61 ± 0.71	2.48 ± 0.69	2.54 ± 0.62	0.411	0.664
HDL (mmol/l)	1.38 ± 0.28	1.72 ± 0.39	1.66 ± 0.38ab	9.800	0.000
LDL (mmol/l)	3.84 ± 0.80	3.59 ± 0.69	3.73 ± 0.99	1.077	0.345
FLI	57.74 ± 17.30	75.89 ± 9.65	89.86 ± 9.56ab	5.286	0.007
FIB−4	1.67 ± 0.44	1.95 ± 0.99	2.46 ± 0.23ab	4.206	0.018
lumbar spine bone density (g/cm2)	0.99 ± 0.44	0.87 ± 0.61	0.75 ± 0.59ab	3.734	0.006

BMI body mass index, WC waist circumference, HbA1c glycated hemoglobin, 25(OH)D 25-hydroxy vitamin D, FPG fasting plasma glucose, ALT alanine transaminase, AST aspartate aminotransferase, γGT gamma-glutamyl transferase, PTH Parathyroid Hormone, TC total cholesterol, TG triglycerides, HDL high density lipoprotein, LDL low density lipoprotein, FLI Fatty liver index score, FIB-4- Fibrosis-4 score

a indicates P<0.05, compare with hepatic steatosis grade 1; b indicates P<0.05, compare with hepatic steatosis grade 2。