Table 2.
Multivariate logistic regression analysis of factors associated with NAFLD in T2DM patients
| Covariate | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| OR | 95% CI | P | OR | 95% CI | P | |
| Age (years) | 1.02 | 0.99–1.07 | < 0.001 | 0.93 | 0.89–0.95 | < 0.001 |
| Sex | ||||||
| Male | ||||||
| Female | 0.68 | 0.55–0.87 | 0.465 | |||
| BMI (kg/m2 ) | 1.12 | 1.02–1.14 | 0.004 | 1.04 | 1.00-1.07 | 0.007 |
| WC (cm) | 1.13 | 1.07–1.15 | 0.038 | 0.83 | 0.79–0.85 | 0.344 |
| HbA1C(%) | 0.93 | 0.88–0.97 | 0.067 | |||
| C-peptide (ng/ml) | 0.73 | 0.69–0.78 | 0.694 | |||
| FPG(mmol/l) | 0.67 | 0.61–0.73 | 0.072 | |||
| ALT(U/L) | 0.66 | 0.62–0.70 | 0.029 | |||
| AST(U/L) | 0.73 | 0.68–0.76 | 0.018 | |||
| 25(OH)D(ng/ml) | 1.17 | 1.14–1.23 | 0.003 | 1.26 | 1.22–1.29 | 0.001 |
| PTH(pg/ml) | 0.13 | 0.07–0.16 | 0.562 | |||
| TC(mmol/l) | 0.46 | 0.42–0.49 | 0.849 | |||
| TG(mmol/l) | 0.69 | 0.63–0.73 | 0.712 | |||
| HDL-C(mmol/l) | 0.34 | 0.30–0.37 | 0.088 | |||
| LDL-C(mmol/l) | 1.28 | 0.24–0.33 | 0.672 | |||
| FLI | 1.18 | 1.14–1.22 | 0.012 | 0.74 | 0.71–0.77 | 0.027 |
| FIB-4 | 1.23 | 1.19–1.27 | 0.025 | 1.09 | 1.06–1.12 | 0.011 |
BMI body mass index, WC waist circumference, HbA1c glycated hemoglobin, 25(OH)D 25-hydroxy vitamin D, FPG fasting plasma glucose, ALT alanine transaminase, AST aspartate aminotransferase, γGT gamma-glutamyl transferase, PTH Parathyroid Hormone, TC total cholesterol TG triglycerides, HDL high density lipoprotein, LDL low density lipoprotein, FLI Fatty liver index score, FIB-4 Fibrosis-4 score
a indicates P<0.05, compare with hepatic steatosis grade 1; b indicates P<0.05, compare with hepatic steatosis grade 2