Table 1.

A schematic diagram of the schedule of enrolment, interventions, assessments, and visits for participants

	Study period
	Enrolment	Allocation	Post-allocation			Close-out
Timepoint	−t1	0	t1	t2	t3	t4
Enrolment
Eligibility screen	X
Informed consent	X
Allocation		X
Interventions
Povidone-iodine irrigation and topical vancomycin powder			X
Povidone-iodine irrigation			X
Assessments
Baseline variables age, gender, BMI, presence of hyper-pressure and metabolic syndrome, ASA class	X	X
Occurrence of PJI				X	X	X
Occurrence of adverse events and harms				X	X	X
Medical cost analysis						X

−t₁, between admission to the hospital and TKA or THA; t₁, TKA or THA; t₂, follow-up visits 2 weeks postoperatively; t₃, follow-up visits 2 weeks postoperatively; t₄, phone contact at 90 days postoperatively