Fig. 5.

Forceps major. A: The lesion topography of alexia patients.¹⁹¹ The dark gray area (highlighted by arrow) indicates the brain lesion site commonly appeared in alexia patients. This area corresponds to the forceps major. Reprinted by permission from reference 191. B: The forceps major (blue) identified by using tractography in dMRI data overlaid on the axial section of a T1-weighted image. C: Tractometry study on the forceps major. Left panel: Tract profile of the forceps major in good (dark green) and poor readers (gray).²⁰² The horizontal axis depicts the normalized position along the forceps major, whereas the vertical axis depicts microstructural measurement (ICVF estimated by NODDI).³⁴ The shaded area indicates ±1 s.e.m. The reading performance was measured by the WJ-BRS. Right panel: the forceps major identified by tractography. Reprinted by permission from reference 202 (under the CC BY-NC-ND license). dMRI, diffusion-weighted MRI; ICVF, intra-cellular volume fraction; NODDI, neurite orientation dispersion and density imaging; WJ-BRS, Woodcock-Johnson Basic Reading Score.