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. 2024 Jul 10;10(28):eadk3365. doi: 10.1126/sciadv.adk3365

Fig. 5. The TAC3R SNP rs2765 decreases functional connectivity between the CeM and the lateral posterior BNST during threatening stimuli processing and reduces TAC3R mRNA expression in men but not in women.

Fig. 5.

(A) Schematic representation of the experimental procedure. Created with BioRender.com. (B) Representative functional magnetic resonance imaging (fMRI) images illustrating the connectivity studied. (C) Left-CeM-BNST activation of the CeM and the BNST during the Hariri task in men. (D) Left-CeM-BNST activation of the CeM and the BNST during the Hariri task in women. (E) Achenbach Adult Self Report Syndrome Scales (ASR) for men. (F) Postmortem brain tissue analysis of TAC3R mRNA expression in men and women with and without the SNP. Data are presented as mean ± SEM except for (F), which is shown as mean ± SD; analyzed using one-way ANOVA, t test, Wald’s chi-square, or Mann-Whitney’s U. *P < 0.05 and **P < 0.01.