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. 2023 Jun 16;2:1183908. doi: 10.3389/frtra.2023.1183908

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© 2023 Rother, Horgby, Schmalkuche, Burgmann, Nocke, Jägers, Schmitz, Bräsen, Cantore, ZLC, Ferenz, Blasczyk and Figueiredo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Histological analyses of kidneys after normothermic EVKP using OCs. Representative images of hematoxylin and eosin stained renal cortex regions: Kidneys perfused with no OCs (A), blood (B), PFC-based OCs (C), or M101 (D) showed necrotic cell detritus within the tubular lumen (blue arrow) as well as a mild tubular vacuolization (black arrow), indicating a potentially reversible mild to moderate acute tubular injury and minor signs of tubular necrosis. However, overall renal morphology of the individual groups was intact (scale bar: 200 µm).