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Cytokine secretion profile during normothermic EVKP using OCs. Concentrations of interleukin (IL)-1β, tumor necrosis factor (TNF)α, IL-6, and IL-8 were measured in perfusates of control kidneys and kidneys exposed to OCs at different time points (0, 60, 120, 180, and 240 min). Graphs represent means and standard deviations (n = 3). IL-6 and IL-8 levels decreased significantly after addition of OCs (**p < 0.01; ***p < 0.001; ****p < 0.0001; two-way ANOVA).
