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. 2023 Jun 16;2:1183908. doi: 10.3389/frtra.2023.1183908

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© 2023 Rother, Horgby, Schmalkuche, Burgmann, Nocke, Jägers, Schmitz, Bräsen, Cantore, ZLC, Ferenz, Blasczyk and Figueiredo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Heatmap representing the gene expression profile of ex-vivo perfused kidneys using OCs. Relative quantification (RQ) of heat shock protein 70 (HSP70), IL-6, IL-8, TNFα, intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), β2-microglobulin (β2 m), and swine leukocyte antigen-DRα (SLA-DRα) gene expression in renal tissues measured by qPCR. The data were normalized to the endogenous housekeeper gene GAPDH. Color intensity represents the up- and downregulation of mRNA expression values relative to the control tissue of non-perfused kidneys. Compared to the kidneys perfused without OCs, IL-6 and ICAM-1 gene expression levels significantly decreased after addition of OCs (*p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001; one-way ANOVA).