TABLE 2.
Comparison of biomarker levels between amyotrophic lateral sclerosis patients and controls.
| Biomarker | N | Patients median (IQR) | N | Controls median (IQR) | P‐value |
|---|---|---|---|---|---|
| SerpinA1CSF, μg/mL | 95 | 4.84 (3.2–6.9) | 9 | 3.64 (2.8–4.8) | 0.291 |
| SerpinA1serum, μg/mL | 110 | 1032 (658.9–1467.9) | 10 | 1343 (1008.1–3047.8) | 0.017 |
| NfLCSF, pg/mL | 73 | 6454 (3261–10,872) | 3 | 220 (109–351) | 0.045 |
| NfLserum, pg/mL | 77 | 111 (73.7–153) | 7 | 5.3 (3.8–8.9) | <0.001 |
| NfHCSF, pg/mL | 110 | 4092.5 (2494–7354) | 10 | 426 (259–598) | <0.001 |
| NfHserum, pg/mL | 108 | 1272 (610.5–2497) | 10 | 118.2 (66.3–191) | <0.001 |
| CHIT3L1CSF, ng/mL | 95 | 73.1 (48.9–131) | 10 | 86.4 (45.6–95) | 0.540 |
| CHIT3L1serum, ng/mL | 108 | 36 (27.3–62.8) | 10 | 39 (32.3–75.4) | 0.389 |
| BBB damage index, % | 49 | 0.49 (0.36–0.65) | 9 | 0.51 (0.44–0.6) | 0.855 |
Note: Data are presented as median (IQR). P‐values inferior to 0.05 were presented in bold character to denote statistical significance.
Abbreviations: BBB damage index, blood–brain barrier damage index, calculated by the ratio of AlbuminCSF/Albuminserum, multiplied per 100; CHI3L1, chitinase‐3‐like protein‐1; IQR, interquartile range; NfL, neurofilament light chain; NfH, neurofilament heavy chain.