TABLE A4.

Comparison of white matter area means of patients with amyotrophic lateral sclerosis at different King's Stages (1–3), with healthy control subjects as reference, with adjustment for age and sex.

Inter‐vertebral disc level	King's Stage	Adjusted mean WM area/SE, mm2	Difference between means/SE	95% CI	95% CI	p
C2/C3	1	62.55/2.16	−5.86/2.43	−10.71	−1.01	0.0185
	2	60.07/2.25	−8.34/2.51	−13.34	−3.33	0.0014
	3	61.35/1.52	−7.06/1.81	−10.68	−3.44	0.0002
	Controls	68.41/1.07
C3/C4	1	62.44/2.07	−6.04/2.32	−10.68	−1.40	0.0115
	2	60.70/2.15	−7.78/2.40	−12.57	−2.99	0.0019
	3	59.34/1.48	−9.14/1.76	−12.66	−5.62	<0.0001
	Controls	68.48/1.03
C4/C5	1	66.12/2.41	−2.20/2.70	−7.59	3.20	0.4191
	2	60.23/2.50	−8.09/2.79	−13.65	−2.52	0.0051
	3	60.52/1.76	−7.79/2.08	−11.95	−3.63	0.0004
	Controls	68.31/1.20
C5/C6	1	62.66/2.31	−2.84/2.59	−8.02	2.34	0.2780
	2	58.35/2.40	−7.15/2.68	−12.50	−1.80	0.0096
	3	56.84/1.69	−8.66/2.00	−12.66	−4.66	<0.0001
	Controls	65.50/1.15
T max	1	34.90/1.64	−2.27/1.85	−5.97	1.42	0.2236
	2	34.68/1.71	−2.49/1.91	−6.32	1.33	0.1973
	3	34.60/1.22	−2.56/1.43	−5.43	0.30	0.0786
	Controls	37.17/0.83

Note: p values after Bonferroni correction with a significance level of <0.0083 are marked in bold.

Abbreviations: CI, confidence interval of the difference between means; WM, white matter; SE, standard error.