FIGURE 7.
(A) Schematic showing wirelessly connected SMND percutaneous drug delivery to a mouse melanoma model. The SMND is mainly composed of a double‐layer MN patch (DLMNP), a heating film, a flexible printed circuit board (FPCB), a smartphone‐based application (APP), and a wristband. (B) Structure of the double‐drug‐containing DLMNP. SF loaded on PD‐1 is the inner matrix of DLMNPs, while PCL encapsulated by AB‐MSN is the outer thermally responsive coating of DLMNPs. (C) Representative photographs in (i) were tumors from treated mice, (ii) tumor growth curve of B16‐CSCs tumor‐bearing mice within 14 days of treatment. All significant differences in the figure are the results of comparison with the PBS group. Reproduced with permission. 39 Copyright 2022, John Wiley and Sons. PBS, phosphate buffered saline.