TABLE 1.
Baseline characteristics of study population.
| Characteristic | MSA | PSP | CBS | APS |
|---|---|---|---|---|
| Patients (n) | 100 | 137 | 74 | 28 |
| Sex |
43 F 57 M |
51 F 86 M |
47 F 27 M |
12 F 16 M |
| Age at symptom onset (years) | 59.2 (9.5) | 65.4 (7.3)*** | 63.3 (7.9)* | 65.8 (10.1)*** |
| Duration at baseline (years) | 5.1 (2.6) | 4.4 (3.1)* | 4.5 (2.4) | 4.3 (2.3) |
| UMSARS total score | 44.0 (15.2) | – | – | – |
| PSPRS total score | – | 33.3 (13.1) | 33.7 (13.0) | 20.3 (9.2) |
| SEADL a | 60% (40%–80%)## | 60% (40%–80%)## | 50% (30%–60%)### | 80% (60%–90%) |
| PEG recommended | 4 | 5 | 0 | 0 |
| PEG inserted | 3 | 1 | 0 | 0 |
| Postural instability | 72 (72%) | 112 (82%) | 41 (55%) | 22 (79%) |
| Using wheelchair outdoors | 30 (30%) | 32 (23%) | 25 (34%) | 3 (11%) |
| Residential or nursing home | 0 (0%) | 3 (2%) | 4 (5%) | 2 (7%) |
| Aspiration pneumonia | 4 (4%) | 5 (4%) | 0 (0%) | 0 (0%) |
| Unintelligible speech | 5 (5%) | 12 (9%) | 4 (5%) | 0 (0%) |
Abbreviations: APS, atypical parkinsonian syndrome, indeterminate; CBS, corticobasal syndrome; F, female; IQR, interquartile range; M, male; MSA, multiple system atrophy; PEG, percutaneous endoscopic gastrostomy; PSP, progressive supranuclear palsy; PSPRS, Progressive Supranuclear Palsy Rating Scale; SD, standard deviation; SEADL, Schwab and England Activities of Daily Living Scale; UMSARS, Unified Multiple System Atrophy Rating Scale.
a
Data are presented as median (IQR). All other continuous data presented as mean (SD).
*p < 0.05, **p < 0.01, ***p < 0.001 vs. MSA; ## p < 0.01, ### p < 0.001 vs. APS (Kruskal–Wallis test followed by post hoc Dunn's test).