TABLE 2.

Pearson correlations between sNfL and small fiber parameters as well as sural nerve NCS.

	IENFD lateral thigh	IENFD lateral calf	CDT	WDT	MDT	MPT	TSL	VDT	Sural nerve SNAP	Sural nerve NCV	Sural/ulnar ratio
sNfL
r	−0.15	−0.28	0.05	0.28	0.12	0.12	−0.03	−0.21	−0.43	−0.26	−0.17
p	0.46	0.14	0.81	0.14	0.56	0.56	0.89	0.28	0.02*	0.17	0.37

Note: There were no significant correlations between sNfL and the other results of SFN assessment in the patient cohort (n = 30), but there was a strong negative correlation with sural nerve SNAP.

Abbreviations: CDT, cold detection threshold; IENFD, intraepidermal nerve fiber density; MDT, mechanical detection threshold; MPT, mechanical pain threshold; NCS, nerve conduction studies; NCV, nerve conduction velocity; SFN, small fiber neuropathy; SNAP, sensory nerve action potential; sNfL, serum neurofilament light chain; TSL, thermal sensory limen; VDT, vibration disappearance threshold; WDT, warm detection threshold. *significant p value.