TABLE 3.

Anchor‐based method (ANCH‐A and ANCH‐B) results.

	SMA type II	SMA type III
ANCH‐A
	>−2	>−4
AUC (95% CI)	0.78 (0.65–0.88)	0.77 (0.55–0.91)
Sensitivity (95% CI)	0.85 (0.70–0.94)	0.85 (0.55–0.98)
Specificity (95% CI)	0.67 (0.35–0.90)	0.64 (0.31–0.89)
ANCH‐B
MCID improvement (95% CI)	1.46 (0.10–2.80)	2.38 (1.44–3.31)
MCID deterioration (95% CI)	−3.21 (−4.90 to −1.53)	−3.20 (−3.45 to −2.94)

Note: MCID improvement/deterioration: the difference between the mean change from HFMSE baseline score of the “stable” group and the mean score of the “improved” (or “deteriorated”) group. Bold indicates values of optimal cutoff.

Abbreviations: AUC, area under the curve; CI, confidence interval; MCID, minimal clinically important difference; SMA, spinal muscular atrophy.