TABLE 2.

Multivariate model for monthly migraine days at the four time points and predictive variables for these.

Variables	β‐coefficient	95% CI	p value
T‐Worsening	0.61	0.53, 0.69	<0.001
T‐Reintroduction	0.07	−0.01, 0.14	0.069
T‐Baseline	0.6	0.52, 0.69	<0.001
Migraine type: CM	0.09	0.00, 0.18	0.048
NSAIDs overuse	0.02	0.01, 0.02	<0.001
Opioids overuse	0	−0.01, 0.02	0.669
Triptans overuse	0.04	0.03, 0.04	<0.001

Abbreviations: CI, confidence interval; CM, chronic migraine; NSAIDs, nonsteroidal anti‐inflammatory drugs; T‐Baseline, month before initiating anti‐CGRP MAb treatment; T‐Worsening, last month before the resumption of treatment; T‐Reintroduction, the third month after anti‐CGRP MAb reintroduction.