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. 2024 Jun 15;16(6):2697–2715. doi: 10.4251/wjgo.v16.i6.2697

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©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Indole-3-acetaldehyde inhibits proliferation of colorectal cancer cells in vitro. A and B: Growth curves of HCT116 and DLD-1 cells treated with IAAD; C and D: Vitality of HCT116 and DLD-1 cells treated with different concentrations of indole-3-acetaldehyde after 48 h, compared with the control group; E and F: The expression of Ki-67 in the nucleus was determined by immunofluorescence. ^aP < 0.05, 50 μmol/L indole-3-acetaldehyde treatment group vs control group; ^bP < 0.01, 50 μmol/L indole-3-acetaldehyde treatment group vs control group; ^dP < 0.01, 100 μmol/L indole-3-acetaldehyde treatment group vs control group. DAPI: 4’,6-diamidino-2-phenylindole.