Table 6.
Comparison of training set and validation set features, n (%)
|
Characteristic
|
Training cohort, n = 84
|
Internal test cohort, n = 36
|
P value
|
| HBV-DNA | 0.749 | ||
| > 2000 | 37 (44) | 17 (47) | |
| ≤ 2000 | 47 (56) | 19 (53) | |
| HBV | 0.001 | ||
| Negative | 67 (80) | 18 (50) | |
| Positive | 17 (20) | 18 (50) | |
| Antiviral therapy | 0.806 | ||
| No | 18 (21) | 7 (19) | |
| Yes | 66 (79) | 29 (81) | |
| Child Pugh score | 0.022 | ||
| A | 30 (36) | 21 (58) | |
| B | 54 (64) | 15 (42) | |
| PVTT | 0.780 | ||
| No | 42 (50) | 19 (53) | |
| Yes | 42 (50) | 17 (47) | |
| BCLC stage | 0.690 | ||
| B | 41 (49) | 19 (53) | |
| C | 43 (51) | 17 (47) | |
| Metastasis | 0.936 | ||
| No | 46 (55) | 20 (56) | |
| Yes | 38 (45) | 16 (44) | |
| AFP | 0.035 | ||
| > 1210 | 48 (57) | 13 (36) | |
| ≤ 1210 | 36 (43) | 23 (64) | |
| Sex | 0.837 | ||
| Female | 31 (37) | 14 (39) | |
| Male | 53 (63) | 22 (61) | |
| Age | 0.968 | ||
| < 60 | 44 (52) | 19 (53) | |
| ≥ 60 | 40 (48) | 17 (47) | |
| BMI | 0.333 | ||
| Low | 48 (57) | 25 (69) | |
| Normal | 5 (6.0) | 3 (8.3) | |
| Obese | 5 (6.0) | 0 (0) | |
| Overweight | 26 (31) | 8 (22) | |
| ECOG | 0.491 | ||
| 0-1 | 48 (57) | 23 (64) | |
| 2 | 36 (43) | 13 (36) | |
| Post operative | 0.569 | ||
| No | 49 (58) | 23 (64) | |
| Yes | 35 (42) | 13 (36) | |
| ALT | 0.262 | ||
| > 40 | 35 (42) | 19 (53) | |
| ≤ 40 | 49 (58) | 17 (47) | |
| Total bilirubin | 0.049 | ||
| > 34 | 62 (74) | 20 (56) | |
| ≤ 34 | 22 (26) | 16 (44) | |
| Diabetes | 0.066 | ||
| No | 59 (70) | 31 (86) | |
| Yes | 25 (30) | 5 (14) | |
| Hypertensive | 0.827 | ||
| No | 24 (29) | 11 (31) | |
| Yes | 60 (71) | 25 (69) | |
| Cirrhosis | 0.245 | ||
| No | 44 (52) | 23 (64) | |
| Yes | 40 (48) | 13 (36) | |
| Smoking | 0.365 | ||
| No | 56 (67) | 27 (75) | |
| Yes | 28 (33) | 9 (25) | |
| Alcohol | 0.228 | ||
| No | 51 (61) | 26 (72) | |
| Yes | 33 (39) | 10 (28) | |
| Virus reactivation | 0.512 | ||
| No | 83 (99) | 35 (97) | |
| Yes | 1 (1) | 1 (3) |
Data in brackets represent the percentages of patients. HBV: Hepatitis B virus; BMI: Body mass index; ECOG: Eastern Cooperative Oncology Group; AFP: Alpha-fetoprotein; ALT: Alanine aminotransferase; BCLC: Barcelona Clinic Liver Cancer; PVTT: Portal vein tumor thrombosis.