Table 1.

Characteristics of included interventions.

Approach	Network-Based Cognitive Training (NBCT)	Home-based Cognitive Rehabilitation (HomeCoRe)	Semantic Memory Rehabilitation Training (SMRT)	Unstructured Home-based Cognitive Stimulation (Sham Comparator)
Participants	40 participants with MCI randomly allocated to NBCT.	5 participants with MCI randomly allocated to HomeCoRe.	10 participants with MCI randomly allocated to SMRT.	55 MCI, randomly assigned to one of three control groups (CG): CG for NBCT (n = 40), CG for HomeCoRe (n = 5), CG for SMRT (n = 10).
Interventions	Cognitive training specifically designed to promote cognitive functions in early stages of neurodegenerative conditions.	Cognitive training specifically designed to promote cognitive functions in early stages of neurodegenerative conditions.	Cognitive training specifically designed to promote cognitive functions in early stages of neurodegenerative conditions.	This activity is commonly used as a control condition to test the efficacy of innovative rehabilitative treatments.
Outcome measures	Primary outcome: Assessment of resting-state functional connectivity at baseline (T0) and at the end of NBCT (T1 after 4 weeks). Secondary outcome: Global cognitive and neuropsychological changes at T1, T2, and T3 vs. T0 when applicable according to Table 1. Secondary outcome measures will also include participant-centered assessment at T1.	Primary outcome: Assessment of resting-state functional connectivity at baseline (T0) and at the end of HomeCoRe (T1 after 6 weeks). Secondary outcome: Global cognitive and neuropsychological changes at T1, T2, and T3 vs. T0 when applicable according to Table 1. Secondary outcome measures will also include participant-centered assessment at T1.	Primary outcome: Assessment of resting-state functional connectivity at baseline (T0) and at the end of SMRT (T1 after 6 weeks). Secondary outcome: Global cognitive and neuropsychological changes at T1, T2, and T3 vs. T0 when applicable according to Table 1. Secondary outcome measures will also include participant-centered assessment at T1.	Primary outcome: Assessment of resting-state functional connectivity at baseline (T0) and at the end of sham intervention (T1 after 4 or 6 weeks). Secondary outcome: Global cognitive and neuropsychological changes at T1, T2, and T3 vs. T0 when applicable according to Table 1. Secondary outcome measures will also include participant-centered assessment at T1.