Table 2.
Risk factors of early recurrence in elderly AF patients after RFCA.
| Variable | Univariable OR (95% CI) |
p-value | Multivariable OR (95% CI) |
p-value |
|---|---|---|---|---|
| Age, years | 1.07 (1.03–1.12) | <0.001 | 1.10 (1.04–1.16) | 0.001 |
| Gender (male vs. female) | 0.98 (0.61–1.58) | 0.928 | ||
| BMI, kg/m2 | 0.97 (0.90–1.05) | 0.456 | ||
| Current smoking | 0.99 (0.60–1.62) | 0.951 | ||
| Current drinking | 1.14 (0.70–1.85) | 0.225 | ||
| Left atrial diameter | 1.13 (1.09–1.18) | <0.001 | 1.13 (1.07–1.20) | <0.001 |
| Left ventricular diameter | 1.11 (1.07–1.15) | <0.001 | 1.07 (1.01–1.14) | 0.015 |
| Ejection fraction | 0.92 (0.90–0.95) | <0.001 | 1.00 (0.92–1.10) | 0.945 |
| Reactive hyperemia index | 0.11 (0.06–0.23) | <0.001 | 0.06 (0.02–0.16) | <0.001 |
| History | ||||
| Hypertension | 1.18 (0.69–2.00) | 0.547 | ||
| Diabetes | 0.85 (0.51–1.42) | 0.542 | ||
| Organic heart disease | 1.50 (0.87–2.59) | 0.146 | ||
| Ischemic stroke | 0.80 (0.34–1.87) | 0.599 | ||
| Peripheral vascular disease | 0.78 (0.48–1.26) | 0.316 | ||
| Previous liver insufficiency | - | 0.999 | ||
| Previous kidney insufficiency | 1.28 (0.13–12.45) | 0.796 | ||
| Hyperlipemia | 1.08 (0.62–1.87) | 0.274 | ||
| Hyperuricemia | 0.76 (0.16–3.53) | 0.726 | ||
| Antiarrhythmic drug | ||||
| Amiodarone | ref | <0.001 | ref | <0.001 |
| Propafenone | 3.19 (1.56–6.68) | 0.002 | 4.23 (1.45–12.35) | 0.008 |
| Sotalol | 3.31 (1.91–5.75) | <0.001 | 6.98 (3.26–14.93) | <0.001 |
| Dronedarone | 1.21 (0.39–3.77) | 0.746 | 1.57 (0.40–6.15) | 0.515 |
| Biomedical indicators | ||||
| Leucocyte | 1.05 (0.91–1.20) | 0.501 | ||
| Hemoglobin | 1.01 (0.99–1.02) | 0.376 | ||
| Platelets | 1.00 (1.00–1.01) | 0.795 | ||
| Hs-CRP | 1.64 (1.19–2.26) | 0.003 | 1.35 (0.85–2.14) | 0.199 |
| Glycosylated hemoglobin | 0.99 (0.82–1.20) | 0.922 | ||
| Creatinine | 1.00 (0.99–1.01) | 0.771 | ||
| Uric acid | 1.00 (1.00–1.00) | 0.963 | ||
| Potassium | 1.11 (0.59–2.09) | 0.748 | ||
| Total cholesterol | 0.92 (0.73–1.16) | 0.493 | ||
| Triglyceride | 1.15 (0.91–1.44) | 0.241 | ||
| LDL-C | 0.90 (0.69–1.17) | 0.426 | ||
| ALT | 0.99 (0.98–1.00) | 0.138 | ||
| D-dimmer | 1.08 (0.83–1.39) | 0.572 | ||
| Prothrombin time | 1.01 (0.92–1.10) | 0.880 | ||
| Activated partial thromboplastin time | 1.03 (1.00–1.07) | 0.079 | 1.03 (0.98–1.09) | 0.230 |
| Hs-cTnI | 1.07 (1.04–1.09) | <0.001 | 1.05 (1.01–1.08) | 0.017 |
| Brain natriuretic peptide | 1.01 (1.01–1.01) | <0.001 | 1.00 (0.99–1.01) | 0.984 |
95% CI, 95% confidence interval; OR, odds ratio; organic heart disease included coronary heart disease, valvular heart disease and cardiomyopathy. AF, atrial fibrillation; ALT, alanine aminotransferase; BMI, body mass index; Hs-CRP, high-sensitivity C-reactive protein; Hs-cTnI, high-sensitivity cardiac troponin I; LDL-C, low-density lipoprotein cholesterol; RFCA, radiofrequency catheter ablation.