TABLE 4.
Inoculum | Finding at indicated wk postchallengea
|
||||||
---|---|---|---|---|---|---|---|
Cat | 6
|
9
|
13
|
||||
VI | IB | TM | VI | IB | VI | ||
Pet challenge | |||||||
PETΔRT + IFNγ | 1 | + | + | 25 | + | + | − |
2 | + | + | 25 | + | + | + | |
3 | + | + | 25 | + | + | − | |
4 | + | + | 25 | + | + | + | |
5 | + | + | 5 | + | + | − | |
6 | − | − | 0 | − | − | − | |
GL8ΔRT + IFNγ | 1 | − | − | 0 | − | − | − |
2 | − | − | 0 | + | + | − | |
3 | + | + | 25 | + | + | + | |
4 | − | − | 0 | − | − | − | |
5 | + | + | 25 | + | + | + | |
6 | + | + | 5 | + | + | + | |
IFN-γ | 1 | + | + | 25 | + | + | + |
2 | + | + | 5 | + | + | − | |
3 | + | + | 5 | + | + | + | |
4 | + | + | 5 | + | + | + | |
5 | + | + | 25 | + | + | + | |
6 | + | − | 25 | + | + | − | |
GL8 challenge | |||||||
PETΔRT + IFNγ | 1 | + | + | 625 | + | + | + |
2 | + | + | 125 | + | + | + | |
3 | + | + | 125 | + | + | + | |
4 | + | ND | ND | ND | ND | ND | |
5 | + | + | 125 | + | + | + | |
6 | + | + | 625 | + | + | + | |
GL8ΔRT + IFNγ | 1 | + | + | 625 | + | + | + |
2 | + | + | 625 | + | + | + | |
3 | + | + | 625 | + | + | + | |
4 | + | + | 25 | + | + | + | |
5 | + | + | 625 | + | + | + | |
IFN-γ | 1 | + | + | 625 | + | + | + |
2 | + | + | 625 | + | + | + | |
3 | + | + | 625 | + | + | + | |
4 | − | − | 0 | − | − | − | |
5 | + | + | 625 | + | + | + | |
6 | + | + | 625 | + | + | + |
At the time of challenge, all cats were negative with respect to immunoblotting (IB), presence (titer) of antibody to TM peptide, and virus isolation (VI). ND, not determined.