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. 2024 Jul 10;14:15996. doi: 10.1038/s41598-024-66637-2

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Gene expression of IGF1, BDNF, and GLUT4 in the hypothalamus. Aβ decreased the expression of IGF1, BDNF, and GLUT4 genes in the hypothalamus. Moderate training exercise along with receiving insulin as treatment and pretreatment significantly increased the mRNA levels of IGF1, BDNF, and GLUT4 in the hypothalamus of rats. Results are shown as mean ± SEM (n = 3 in each group).