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. 2024 Jul 10;15:5790. doi: 10.1038/s41467-024-49595-1

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Heatmap of three distinct immunologic clusters of BRAF mutant LGG showing expression of selected genes of interest. (DIA/DIG: desmoplastic infantile astrocytoma/ganglioglioma; PXA: pleomorphic xantho-astrocytoma; LGG/GNT NOS: low-grade glioma/glioneuronal tumor, not otherwise specified; NB: normal brain). b PCA plot of three LGG clusters and BRAF V600E mutant PHGG compared to normal brain. c Boxplot of TIS scores for three LGG clusters and BRAF V600E mutant PHGG compared to normal brain. Boxes show the median and interquartile range (IQR) of the data with whiskers extending to ±1.5 IQR. P-values by two-tailed T test with Holm adjustment. d Kaplan-Meier curves of progression-free survival for the three LGG immune clusters and of cluster 1 compared to cluster 2 + 3. P-values by log-rank test.