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. 2024 Jul 10;15:5790. doi: 10.1038/s41467-024-49595-1

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Scatter plot comparing longitudinal TIS scores pre- and post-ICI treatment in four MMRD HGGs with matched tissue samples. b Heatmap of NanoString counts for selected genes pre- and post-ICI treatment for four patients with longitudinal sampling. c Representative MRI and histology (CD8 and PD-L1 IHC) images of pre-ICI treatment and post-treatment samples from a patient with MMRD HGG. Scale bars (bottom left) are 100 μm for CD8 (images taken at ×100 magnification) and 50 μm for PD-L1 (images taken at ×200 magnification).