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. 2024 Jul 10;14:15982. doi: 10.1038/s41598-024-53870-y

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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IHC staining of Maspin in samples of primary breast cancer tumors and its expression profile in different molecular subgroups. Image above representative photomicrographs of tumor tissues classified as high and low for Maspin in the TN (A and D, respectively), HER2+ (B and E, respectively) and Luminal (C and F, respectively) subtypes. Image below IHC expression levels of Maspin between the different molecular groups and according to the cytoplasmic and nuclear location in breast cancer cells (A and B, respectively). IHC expression levels of Maspin between the different molecular groups and according to the protein present in the tumor microenvironment (C). Statistical analyzes of the box plots were performed using the t-student or Mann–Whitney test as appropriate, with data expressed as mean ± s.e.m. (standard error). The following H-score medians were obtained for the Maspin: Cytoplasm 71.07, Nucleus 145.84, and Stroma 19.32, and subsequently, Kaplan Meyer (KM) curves were elaborated according to follow up patients’ data. *p < 0.05; **p < 0.01; ***p < 0.001.