Fig. 5. Genotyped SNP-based heritability of, and genetic correlation between, baseline obesity trait and obesity-change phenotypes.

Left column: heritability ($h_G^2$) estimate means and 95% CI, calculated using the LDSC software⁶⁷ on a subset of 1 million HapMap3 SNPs¹³³ for the following traits: baseline BMI and weight, estimated from intercepts of linear mixed-effects models of obesity traits over time (u0), linear slope change in obesity traits over time (u1 adj. u0), adjusted for intercepts, and posterior probability of membership in a high-gain BMI or weight cluster, adjusted for baseline trait value (prob(k1) adj. u0). Right column: Genetic correlation, r_G means and 95% CI between the obesity-change and baseline obesity. In all panels, summary statistics for correlations and heritability are derived from discovery studies with sample sizes for: BMI = 87,908 females and 73,656 males; weight = 96,264 females and 80,144 males. Circles represent BMI, triangles represent weight; points are coloured by analysis strata (pink: female-sepcific, green: male-specific, grey: sex-combined). P values display the level of significance of heterogeneity between the female- and male-specific estimates in each panel.