Table 2.
Lead SNPs identified from genome-wide association studies (GWAS) of posterior probability of membership in an adiposity-change cluster (high gain k1, high/moderate gain k1/k2, or high/moderate gain and steady k1/k2/k3), independent of baseline obesity
| Trait | SNP | chr:pos (hg37) | MAF | Nearest TSS | Adiposity-change cluster | Sex-combined OR (95% CI) | Sex-combined P value | Female OR (95% CI) | Female P value | Male OR (95% CI) | Male P value | Sex-heterogeneity P value |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Weight | rs9467663 | 6:26021456 | 0.418 | H4C1 | k1 | 1.01 (1.01–1.01) | 1.6e-09 | 1.01 (1.01–1.02) | 4e-06 | 1.01 (1–1.01) | 0.00081 | 0.785 |
| BMI | chr6:26076446 | 6:26076446 | 0.437 | HFE | k1 | 1.01 (1.01–1.02) | 2.1e-09 | 1.01 (1.01–1.02) | 7.1e-06 | 1.01 (1.01–1.02) | 2.7e-05 | 0.478 |
| BMI | rs11778922* | 8:20493349 | 0.379 | LZTS1 | k1 | 0.99 (0.987–0.994) | 2.1e-06 | 0.984 (0.979–0.99) | 1.3e-08 | 0.998 (0.992–1) | 0.41 | 0.000578 |
| BMI | rs61955499* | 13:112565161 | 0.012 | SOX1 | k1, k2, or k3 | 0.978 (0.961–0.995) | 0.012 | 0.935 (0.913–0.958) | 3.4e-08 | 1 (0.978–1.03) | 0.78 | 4.71e-05 |
| Weight | rs12953815* | 18:2586907 | 0.496 | NDC80 | k1, k2, or k3 | 1 (1–1.01) | 0.02 | 1 (0.995–1) | 0.97 | 1.01 (1.01–1.02) | 1.7e-08 | 2.03e-05 |
| BMI | rs429358 | 19:45411941 | 0.156 | APOE | k1 | 1.02 (1.02–1.03) | 4.9e-19 | 1.03 (1.02–1.03) | 3e-12 | 1.02 (1.01–1.03) | 5.2e-08 | 0.764 |
| BMI | rs429358 | 19:45411941 | 0.156 | APOE | k1 or k2 | 1.02 (1.02–1.03) | 1.1e-17 | 1.02 (1.02–1.03) | 2.6e-11 | 1.02 (1.01–1.03) | 5.4e-08 | 0.689 |
| BMI | rs429358 | 19:45411941 | 0.156 | APOE | k1, k2, or k3 | 1.02 (1.02–1.03) | 2.5e-16 | 1.02 (1.02–1.03) | 9.3e-11 | 1.02 (1.01–1.03) | 2.5e-07 | 0.714 |
| Weight | rs429358 | 19:45411941 | 0.156 | APOE | k1 | 1.02 (1.02–1.03) | 1.8e-20 | 1.02 (1.02–1.03) | 1.5e-11 | 1.02 (1.01–1.03) | 8.9e-08 | 0.807 |
| Weight | rs429358 | 19:45411941 | 0.156 | APOE | k1 or k2 | 1.02 (1.02–1.03) | 2.7e-19 | 1.02 (1.02–1.03) | 6.6e-12 | 1.02 (1.01–1.02) | 6.8e-07 | 0.886 |
| Weight | rs429358 | 19:45411941 | 0.156 | APOE | k1, k2, or k3 | 1.02 (1.02–1.03) | 1.8e-17 | 1.02 (1.02–1.03) | 1e-10 | 1.02 (1.01–1.02) | 4.3e-06 | 0.875 |
Variants marked with * have 5 × 10−8 > P value > 1 × 10−8. MAF minor allele frequency (European-ancestry), TSS transcription start site, SE standard error, OR odds ratio, CI confidence interval.