Most prominent cellular effects of CB2R activation. An overview of the cellular responses elicited by CB2R activation, including the activation of MAPK pathways (ERK1/2, P38) important for cell growth and inflammatory responses, autophagy induction for cellular homeostasis, apoptosis in immune cells, modulation of phagocytosis, and promotion of M2 macrophage polarization, illustrating CB2R’s role in immune regulation and its potential for treating inflammation-related conditions.