TABLE 6.
Interpretive categorical agreement based on modal MIC category for 140 S. pneumoniae from six ICS laboratories using broth microdilution, Etest, or disc diffusionc
| ICS QC laboratory | # of results available | CLSIa | EUCASTb | ||
|---|---|---|---|---|---|
| Categorical errors | Categorical agreement (%) | Categorical errors | Categorical agreement (%) | ||
| A | 1,239 MIC |
13 MI (4 PEN, 1 CRO, 4 CTX, 4 SXT); 2 VM (CHL) |
98.8 (1,224/1,239) | 7 MI (4 PEN, 1 CRO, 2 SXT); 1 MA (SXT) |
99.4 (1,231/1,239) |
| B | 1,185 MIC; 26 DD | 12 MI (6 PEN, 1 CLI, 5 SXT); 17 MA (14 CHL, 1 CLI, 1 ERY, 1 SXT); 6 VM (1 CHL, 1 ERY, 4 SXT) |
97.1 (1,176/1,211) | 18 MI (5 PEN, 4 CRO, 2 CTX, 7 SXT); 10 MA (8 CHL, 1 CLI, 1 ERY); 6 VM (1 ERY, 5 SXT) |
97.2 (1,177/1,211) |
| C | 1,067 MIC |
12 MI (2 PEN, 3 CRO, 3 CTX, 4 SXT); 1 VM (CHL) |
98.8 (1,054/1,067) | 7 MI (4 PEN, 1 CRO, 1 CTX, 1 SXT); 1 VM (SXT) |
99.3 (1,059/1,067) |
| D | 268 MIC; 791 DD |
32 MI (11 PEN, 6 CRO, 2 CLI, 1 ERY, 12 SXT); 1 MA (SXT); 3 VM (CHL) |
96.6 (1,023/1,059) |
23 MI (8 PEN, 8 CRO, 7 SXT); 3 MA (2 CLI, 1 SXT); 2 VM (1 ERY, 1 SXT) |
97.4 (1,031/1,059) |
| E | 1190 MIC |
7 MI (1 PEN, 2 CLI, 2 ERY, 2 SXT); 3 MA (2 CHL, 1 LEV), 1 VM (PEN) |
99.1 (1,179/1,190) | 7 MI (3 PEN, 4 SXT); 2 MA (1 CLI, 1 ERY); 1 VM (SXT) |
99.2 (1,180/1,190) |
| F | 1,055 MIC |
12 MI (5 PEN, 2 CRO, 1 CLI, 2 ERY, 2 SXT); 2 MA (1 CHL, 1 CLI) |
98.7 (1,041/1,055) |
11 MI (6 PEN, 3 CRO, 2 SXT); 3 MA (2 CLI, 1 ERY); 1 VM (CHL) |
98.6 (1,040/1,055) |
| Total | 6,004 MIC, 817 DD |
88 MI (29 PEN, 12 CRO, 7 CTX, 6 CLI, 5 ERY, 29 SXT); 23 MA (17 CHL, 2 CLI, 1 ERY, 1 LEV, 2 SXT); 13 VM (1 PEN, 7 CHL, 1 ERY, 4 SXT) |
98.2 (6,697/6,821) | 73 MI (30 PEN, 17 CRO, 3 CTX, 23 SXT); 19 MA (8 CHL, 6 CLI, 3 ERY, 2 SXT); 11 VM (1 CHL, 2 ERY, 8 SXT) |
98.5 (6,718/6,821) |
Using CLSI M100, 33rd Edition, 2023. For β-lactams, breakpoints used were as follows: oral penicillin V, ceftriaxone, and cefotaxime non-meningitis.
Using EUCAST Breakpoint tables for interpretation of MICs, Version 13.0, 2023. For β-lactams, breakpoints used were benzylpenicillin; ceftriaxone, and cefotaxime for indications other than meningitis.
MI, minor error (intermediate to susceptible/resistant OR susceptible/resistant to intermediate); MA, major error (false resistance); VM, very major error (false susceptibility); PEN, penicillin; CRO, ceftriaxone; CTX, cefotaxime; CHL, chloramphenicol; CLI, clindamycin; ERY, erythromycin; LEV, levofloxacin; SXT, trimethoprim/sulfamethoxazole.