Figure 1.

TaVNS improves anxiety and sociability deficits in poly(I:C)-induced ASD model mice. (A) Schematic diagram of the experiment. Behavioral tasks were performed at 6 w, and taVNS-1/2 or sham stimulus intervention was performed daily for 7 days; subsequently, the behavioral tasks were performed. (B) Schematic diagram of the open field test in mice. Mice in each group were tested in the open field for 5 min. (C, D) Results of the open field test after intervention. Statistical results showed significant changes in the time spent in the center, and no significant difference in the distance (n= 9, 7, 7, and 6). (E) Schematic diagram of a three-chamber social experiment. Mice were tested for 10 min each in three stages. (F-I) Results of the three-chamber sociability test after intervention. Statistical results showed significant differences in the exploration time to new mice (n=11, 7, 7, and 7). (J) Heatmap of the three-chamber social experiment in mice.