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. 2024 Jun 27;15:1393549. doi: 10.3389/fpsyt.2024.1393549

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Copyright © 2024 Zhang, Mou, Zhong, Liu, Yan, Gou, Chen, So and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TaVNS intervention reduces the number of microglia and M1 polarization. (A) Immunofluorescence staining of IBA-1 and DAPI in the prefrontal cortex (scale bars, 100 μm). (B) Coronal section displaying the mPFC (scale bars, 30 μm). (C) Count of IBA-1⁺ cells in the mPFC. Statistical results showed significant changes in IBA-1⁺ cells (n=4 in each group). (D) The number of CD16⁺ cells in the mPFC. Statistical results showed significant changes in CD16⁺ cells (n=10 in each group). (E) Immunofluorescence staining of CD16 and DAPI in the prefrontal cortex (scale bars, 100 μm).