TABLE 5.
Performance of Ag-RDTs in diagnosing SARS-CoV-2 in symptomatic and asymptomatic participantsa
| FlA | LFIA | |||
|---|---|---|---|---|
| Symptomatic | Asymptomatic | Symptomatic | Asymptomatic | |
| Sensitivity | 86.05 (72.07–94.70) | 73.68 (56.90–86.60) | 86.05 (72.07–94.70) | 65.79 (48.64–80.37) |
| Specificity | 83.33 (51.58–97.91) | 97.71 (94.25–99.37) | 91.67 (61.52–99.79) | 97.71 (94.25–99.37) |
| LR+ | 5.16 (1.45–18.40) | 32.24 (12.01–86.51) | 10.33 (1.58–67.69) | 28.78 (10.64–77.89) |
| LR– | 0.17 (0.08–0.37) | 0.27 (0.16–0.46) | 0.15 (0.07–0.33) | 0.35 (0.23–0.54) |
| PPV | 65.05 (34.31–86.90) | 92.08 (81.24–96.89) | 77.49 (34.43–95.76) | 90.56 (78.00–96.29) |
| NPV | 94.31 (88.32–97.32) | 91.15 (85.81–94.61) | 95.17 (90.20–97.69) | 89.55 (84.64–93.02) |
| Accuracy | 84.05 (71.68–92.53) | 91.35 (86.73–94.76) | 90.26 (79.22–96.60) | 89.73 (84.85–93.46) |
| AUC | 0.85 (71.68–92.53) | 0.86 (0.80–0.90) | 0.89 (0.78–0.96) | 0.82 (0.76–0.87) |
a
LR+/–: positive and negative likelihood ratio; PPV: positive predictive value; NPV: negative predictive value; AUC= area under the curve; FIA = SD Biosensor Standard F COVID-19 Ag Test; LFIA = Sure Status COVID-19 Antigen Card Test.