TABLE 1.
Comparison of viral ligands and cellular receptors implicated in attachment and entry of three major betaherpesviruses HCMV, HHV-6, and HHV-7a
| HCMV | HHV-6 | HHV-7 | |||||
|---|---|---|---|---|---|---|---|
| Viral ligand | Cellular receptor | Viral ligand | Cellular receptor | Viral ligand | Cellular receptor | Reference | |
| Attachment | gB and gM/gN | HSPGs | gQ1/gQ2? | HSPGs? | gB and gQ | HSPGs | (11, 12) |
| Binding and entry | gH/gL/gO | PDGFR-α | gH/gL/gO | Unknown | gH/gL/gO? | CD4 | (11, 17) |
| gH/gL/pUL128/pUL130/pUL131A | NRP2 | gH/gL/gQ1/gQ2 | CD46 (HHV-6A) and CD134 (HHV-6B) | gH/gL/gQ | Unknown | Speculative | |
| gB | None, EGFR, PDGFRα, integrins | gB | None or unknown | gB | None or unknown | (17) | |
a
The former two have been extensively reviewed by Nishimura and Mori (30) and specific references are provided for HHV-7. HSPGs: heparan sulfate proteoglycans; PDGFR-α: platelet-derived growth factor receptor A; NRP2: neuropilin 2; EGFR: epidermal growth factor receptor; ?: research indicates, but does not prove, interaction.