Skip to main content
. 2024 May 8;15(6):e00966-24. doi: 10.1128/mbio.00966-24

Fig 1.

Illustrations feature the molecular structure of MMV1557817 with Ki values against different enzymes and the binding mode of MMV1557817 to PfA-M1 and PfA-M17.

MMV1557817 is a potent dual inhibitor of Plasmodium M1 and M17 aminopeptidases. (A) Chemical structure of MMV1557817. Inhibition constants (Kiapp, in nM) for MMV1557817 toward recombinant, purified PfA-, Pv-, and Pb-M1 and PfA-, Pv-, and Pb-M17 are shown underneath panels with the standard error of mean indicated. (B and C) Binding mode of MMV1557817 to PfA-M1 (B) and PfA-M17 (C). Interactions between MMV1557817 (magenta sticks) and protein residues (grey) shown as black dashed lines. Residues of interest are indicated.