Figure 4.

Body composition and glucose homeostasis are altered in Lrp2 KO mice after Western diet. Control and Lrp2 KO mice were placed on a Western diet for 9 wk and analyzed as in Figure 2. Body weight (A) and composition (B) of control and Lrp2 KO mice are plotted. Data analyzed by an unpaired t-test with multiple comparisons correction (Holm-Sidak). (C) Temporal changes in plasma glucose following intraperitoneal injection of 1.5 mg/kg glucose in fasted control and Lrp2 KO mice. AUC for glucose calculated in panel C is shown in (D). (P-values denoted by asterisk: ^****≤0.0001.) Data analyzed by an unpaired t-test.