Figure 1.

CETP expression impairs the anticontractile effect of PVAT in male but not in female mice. Concentration-response curves to phenylephrine (PE) in aortas with (PVAT+, empty circles) or without PVAT (PVAT−, filled circles) from male NTg to hCETP mice (A) and from female NTg to hCETP mice (B). PE-induced contraction is expressed as millinewton (mN) per aorta length in millimeters (mm). Bar graphs represent maximum responses (Emax) to PE in males (A) and females (B). Data are mean ± SE; the number of animals in each group is in parenthesis. *P ≤ .05 and **P ≤ .01 by ANOVA two-way.