Table 3.
Prediction of FOXP4 nsSNPs effect on secondary and tertiary protein structure using GOR IV.
| Parameter | Normal protein | Q156H | T330I | Q355H | R373W | D667H | D669H | L679P |
|---|---|---|---|---|---|---|---|---|
| Alpha helix | 237 (34.85 %) | 237 (34.85 %) | 241 (35.44 %) | 237 (34.85 %) | 236 (34.71 %) | 236 (34.71 %) | 236 (34.71 %) | 236 (34.71 %) |
| 310 helix | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Pi helix | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Beta bridge | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Extended strand | 58 (8.53 %) | 58 (8.53 %) | 58 (8.53 %) | 58 (8.53 %) | 58 (8.53 %) | 58 (8.53 %) | 58 (8.53 %) | 58 (8.53 %) |
| Beta turn | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Bend region | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Random coil | 385 (56.62 %) | 385 (56.62 %) | 381 (56.03 %) | 385 (56.62 %) | 386 (56.76 %) | 386 (56.76 %) | 386 (56.76 %) | 386 (56.76 %) |
| Ambiguous states | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Other states | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |