Table 5.
Prediction of destabilizing effects upon nsSNPs of FOXP4 gene.
| Sl | SNP ID | Amino Acid Change | mCSM |
SDM |
DUET |
|||
|---|---|---|---|---|---|---|---|---|
| Prediction | ΔΔG (kcal/mol) | Prediction | ΔΔG (kcal/mol) | Prediction | ΔΔG (kcal/mol) | |||
| 1 | rs141899153 | Q156H | Destabilizing | −0.745 | Reduced stability | −0.79 | Destabilizing | −0.705 |
| 2 | rs376938850 | T330I | Destabilizing | −0.048 | Reduced stability | −1.5 | Stabilizing | 0.434 |
| 3 | rs112517943 | Q355H | Destabilizing | −0.791 | Reduced stability | −0.77 | Destabilizing | −0.648 |
| 4 | rs140387832 | R373W | Destabilizing | −0.495 | Reduced stability | −0.15 | Destabilizing | −0.477 |
| 5 | rs373949416 | D667H | Stabilizing | 0.438 | Stabilizing | 0.56 | Stabilizing | 0.584 |
| 6 | rs373949416 | D669H | Stabilizing | 0.447 | Stabilizing | 0.8 | Stabilizing | 0.643 |
| 7 | rs376160648 | L679P | Destabilizing | −0.593 | Reduced stability | −1.44 | Destabilizing | −0.61 |