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. 2024 Jun 27;14:1393414. doi: 10.3389/fonc.2024.1393414

Table 1.

Summary of demographic and US features for the patients with thyroid nodules.

Characteristics Final pathology Total p
Benign Malignant
No. Of nodules 329 1,824 2,153
Age 0.000
 Mean (years) 48.9 ± 12.7 44.2 ± 11.5 44.9 ± 11.8
 Range (years) 14–77 9–79 9–79
 <55 211 (64.1) 1,459 (80.0) 1,670 (77.6) 0.000
 ≥55 118 (35.9) 365 (20.0) 483 (22.4)
Gender 0.005
 Male 56 (17.0) 440 (24.1) 496 (23.0)
 Female 273 (83.0) 1,384 (75.9) 1,657 (77.0)
Size 0.000
 Mean (mm) 22.0 ± 17.5 9.9 ± 8.2 11.7 ± 11.1
 Range (mm) 2.5–70.0 1.8–81.0 1.8–81.0
 <10mm 122 (37.1) 1,238 (67.9) 1,360 (63.2) 0.000
 ≥10mm 207 (62.9) 586 (32.1) 793 (36.8)
Ultrasound Features
Composition 0.000
 Mixed cystic and solid 116 (35.3) 47 (2.6) 163 (7.6)
 Solid or almost solid 213 (64.7) 1,777 (97.4) 1,990 (92.4)
Echogenicity 0.000
 Isoechogenicity 101 (30.7) 17 (0.9) 118 (5.5)
 Hyperechogenicity 10 (3.0) 0 (0.0) 10 (0.5)
 Hypoechogenicity 202 (61.4) 1,260 (69.1) 1,462 (67.9)
 Marked hypoechogenicity 16 (4.9) 547 (30.0) 563 (26.1)
Shape 0.000
 Parallel 256 (77.8) 585 (32.1) 841 (39.1)
 Nonparallel 73 (22.2) 1,239 (67.9) 1,312 (60.9)
Margin 0.000
 Smooth 163 (49.5) 109 (6.0) 272 (12.6)
 Ill-defined 137 (41.6) 816 (44.7) 953 (44.3)
 Irregular or lobulated 29 (8.9) 899 (49.3) 928 (43.1)
Echogenic foci 0.000
 No 193 (58.7) 660 (36.2) 853 (39.6)
 Comet-tail 22 (6.7) 6 (0.3) 28 (1.3)
 Macrocalcifications 45 (13.7) 72 (3.9) 117 (5.4)
 Peripheral calcifications 6 (1.8) 4 (0.2) 10 (0.5)
Punctate echogenic foci 63 (19.1) 1,082 (59.4) 1,145 (53.2)

Data in parentheses are percentages.