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. 2024 May 13;35(6):mr3. doi: 10.1091/mbc.E24-02-0093

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© 2024 Holland et al. “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society for Cell Biology.

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FIGURE 6: — Schematic of LifeAct-MTED/scramble effects on MT invasions of dendritic spines. (A) Section of a representative dendritic arbor with one spine boxed. (B) Representative dendritic spine (yellow) rich with f-actin (red filaments) being invaded by a polymerizing MT (green). Other noninvading MTs are shown in the dendrite shaft (unpublished data). (C) Dendritic spine (yellow) of neuron transfected with LifeAct-scramble (blue and gray fusion protein) that is appropriately localizing to actin filaments (red) but does not affect the likelihood of a MT (green) directly polymerizing into the dendritic spine. (D) Dendritic spine (yellow) of neuron transfected with LifeAct-MTED (pink and gray fusion protein) that has localized to actin filaments (red) in the spine head and neck. LifeAct-MTED is shown depolymerizing a MT (green) before its entry into the dendritic spine. Created with BioRender.com.