TABLE 7.
Mutant frequencies in recovered HIV-1 proviruses replicated by AZT- or 3TC-resistant HIV-1 RT variants
| RT | Relative amt of virus production | No. of independent mutants/total no. of bacterial colonies | Mutant frequencya (no. of mutations/cycle | Relative mutant frequency |
|---|---|---|---|---|
| Wild type | 1 | 7/2,029 | 0.003 | 1 |
| 10/1,726 | 0.006 | |||
| 7/2,043 | 0.003 | |||
| 9/1,892 | 0.005 | |||
| T215Y | 0.9 | 12/2,385 | 0.005 | 1.3 |
| 10/1,979 | 0.005 | |||
| 13/2,723 | 0.004 | |||
| M41L/T215Y | 0.6 | 27/2,417 | 0.011 | 3.3 |
| 19/1,150 | 0.017 | |||
| 17/1,438 | 0.012 | |||
| M41L/D67N/K70R/ T215Y | 0.4 | 23/1,522 | 0.015 | 4.3 |
| 44/2,378 | 0.019 | |||
| 17/1,043 | 0.016 | |||
| M184V | 1 | 7/1,904 | 0.004 | 0.8 |
| 3/1,709 | 0.002 | |||
| 4/1,233 | 0.003 |
a
Standard deviations are 0.003, 0.001, 0.005, 0.004, and 0.001 mutant/cycle for mutant frequencies with wild-type, T215Y, M41L/T215Y, M41L/D67N/K70R/T215Y, and M184V RT.