Table 2.
Baseline levels of laboratory characteristics according to TyG Index, METS-IR, TG/HDL-C and HOMA-IR quartiles, NHANES 2001–2018
| Overall | TyG index levels | METS-IR levels | TG/HDL-C levels | HOMA-IR levels | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Characteristic | N | Overall, N = 14,653 | Q1, N = 3325 (22.69%) | Q2, N = 3658 (24.96%) | Q3, N = 3824 (26.10%) | Q4, N = 3846 (26.25%) | P Value | Q1, N = 3416 (23.31%) | Q2, N = 3719 (25.38%) | Q3, N = 3764 (25.69%) | Q4, N = 3754 (25.62%) | P Value | Q1, N = 3417 (23.32%) | Q2, N = 3684 (25.14%) | Q3, N = 3668 (25.03%) | Q4, N = 3884 (26.51%) | P Value | Q1, N = 3810 (26.00%) | Q2, N = 3643 (24.86%) | Q3, N = 3714 (25.35%) | Q4, N = 3486 (23.79%) | P Value |
| HbA1C, % | 14,622 | 5.57 (0.90) | 5.27 (0.43) | 5.40 (0.49) | 5.53 (0.65) | 6.06 (1.43) | < 0.001 | 5.28 (0.45) | 5.43 (0.66) | 5.59 (0.87) | 5.97 (1.27) | < 0.001 | 5.36 (0.57) | 5.47 (0.75) | 5.61 (0.90) | 5.80 (1.18) | < 0.001 | 5.30 (0.52) | 5.38 (0.56) | 5.56 (0.75) | 6.15 (1.40) | < 0.001 |
| FINS, pmol/L | 14,653 | 73.43 (80.65) | 45.30 (37.02) | 59.12 (50.71) | 79.26 (62.74) | 109.22 (126.05) | < 0.001 | 36.42 (24.52) | 52.01 (33.99) | 75.19 (49.25) | 130.85 (129.30) | < 0.001 | 44.50 (42.59) | 59.98 (50.90) | 78.74 (69.16) | 107.68 (118.35) | < 0.001 | 26.29 (8.34) | 47.89 (7.96) | 76.92 (15.23) | 163.96 (135.17) | < 0.001 |
| FPG, mmol/L | 14,653 | 5.80 (1.61) | 5.15 (0.54) | 5.46 (0.70) | 5.74 (0.97) | 6.83 (2.66) | < 0.001 | 5.23 (0.72) | 5.54 (0.97) | 5.87 (1.47) | 6.57 (2.40) | < 0.001 | 5.38 (0.97) | 5.59 (1.20) | 5.85 (1.52) | 6.32 (2.23) | < 0.001 | 5.17 (0.71) | 5.47 (0.79) | 5.82 (1.17) | 7.01 (2.66) | < 0.001 |
| LDL-C, mmol/L | 14,343 | 2.98 (0.91) | 2.60 (0.74) | 2.99 (0.83) | 3.18 (0.91) | 3.15 (1.01) | < 0.001 | 2.75 (0.85) | 3.03 (0.91) | 3.16 (0.92) | 3.00 (0.90) | < 0.001 | 2.66 (0.78) | 2.97 (0.85) | 3.12 (0.91) | 3.17 (0.99) | < 0.001 | 2.86 (0.88) | 3.05 (0.88) | 3.08 (0.94) | 2.96 (0.91) | < 0.001 |
| HDL-C, mmol/L | 14,653 | 1.39 (0.42) | 1.64 (0.45) | 1.47 (0.39) | 1.32 (0.34) | 1.13 (0.29) | < 0.001 | 1.74 (0.44) | 1.44 (0.34) | 1.25 (0.28) | 1.12 (0.28) | < 0.001 | 1.81 (0.43) | 1.47 (0.29) | 1.26 (0.25) | 1.04 (0.22) | < 0.001 | 1.60 (0.44) | 1.43 (0.40) | 1.30 (0.37) | 1.16 (0.29) | < 0.001 |
| TC, mmol/L | 14,653 | 5.04 (1.08) | 4.54 (0.88) | 4.92 (0.94) | 5.18 (1.00) | 5.51 (1.22) | < 0.001 | 4.92 (1.00) | 5.03 (1.05) | 5.15 (1.10) | 5.07 (1.14) | < 0.001 | 4.78 (0.95) | 4.91 (0.99) | 5.04 (1.03) | 5.41 (1.21) | < 0.001 | 4.94 (1.03) | 5.09 (1.05) | 5.14 (1.12) | 5.02 (1.11) | < 0.001 |
| TG, mmol/L | 14,653 | 1.50 (1.35) | 0.63 (0.15) | 1.01 (0.15) | 1.47 (0.25) | 2.86 (2.11) | < 0.001 | 0.93 (0.46) | 1.23 (0.66) | 1.62 (1.04) | 2.22 (2.16) | < 0.001 | 0.66 (0.19) | 1.01 (0.22) | 1.42 (0.31) | 2.79 (2.07) | < 0.001 | 1.06 (0.88) | 1.33 (1.05) | 1.69 (1.40) | 2.05 (1.83) | < 0.001 |
| Scr, umol/L | 14,638 | 78.71 (34.06) | 75.07 (34.42) | 78.36 (30.96) | 80.10 (33.53) | 81.14 (36.90) | < 0.001 | 75.38 (36.43) | 80.28 (37.93) | 79.85 (26.35) | 79.42 (33.93) | < 0.001 | 75.05 (33.07) | 77.62 (33.58) | 79.89 (32.78) | 81.99 (36.12) | < 0.001 | 78.55 (42.81) | 78.83 (36.97) | 78.62 (26.55) | 78.90 (23.01) | 0.011 |
| Uric acid, umol/L | 14,638 | 327.62 (82.37) | 290.17 (72.04) | 316.37 (75.90) | 341.18 (79.50) | 361.19 (84.08) | < 0.001 | 283.23 (69.26) | 318.32 (74.40) | 342.25 (77.56) | 367.79 (83.07) | < 0.001 | 288.44 (70.76) | 315.05 (74.99) | 338.11 (80.52) | 365.48 (82.04) | < 0.001 | 298.61 (73.66) | 317.57 (76.08) | 340.39 (80.29) | 364.17 (86.23) | < 0.001 |
| BUN, mmol/L | 14,639 | 4.72 (1.86) | 4.48 (1.64) | 4.65 (1.78) | 4.76 (1.92) | 4.97 (2.05) | < 0.001 | 4.45 (1.74) | 4.77 (1.80) | 4.78 (1.81) | 4.87 (2.07) | < 0.001 | 4.61 (1.73) | 4.66 (1.79) | 4.74 (1.94) | 4.84 (1.97) | < 0.001 | 4.54 (1.79) | 4.69 (1.86) | 4.76 (1.73) | 4.93 (2.08) | < 0.001 |
| Albumin, g/L | 14,639 | 42.66 (3.17) | 43.02 (3.18) | 42.66 (3.16) | 42.51 (3.15) | 42.48 (3.17) | < 0.001 | 43.55 (3.15) | 43.02 (3.00) | 42.58 (2.92) | 41.48 (3.24) | < 0.001 | 42.95 (3.11) | 42.73 (3.22) | 42.38 (3.24) | 42.60 (3.10) | < 0.001 | 43.16 (3.18) | 42.91 (3.07) | 42.65 (3.02) | 41.70 (3.26) | < 0.001 |
| LDH, IU/L | 14,619 | 127.49 (28.92) | 124.76 (28.15) | 127.81 (32.93) | 128.30 (26.44) | 128.96 (27.47) | < 0.001 | 123.02 (26.53) | 126.34 (25.68) | 128.56 (33.78) | 132.17 (28.42) | < 0.001 | 127.09 (27.25) | 126.65 (26.85) | 127.80 (33.43) | 128.41 (27.83) | 0.12 | 126.06 (29.73) | 126.23 (26.16) | 127.45 (32.45) | 131.00 (26.22) | < 0.001 |
| ALT, IU/L | 14,623 | 25.88 (26.36) | 21.62 (22.87) | 23.62 (15.34) | 26.84 (17.12) | 31.34 (41.24) | < 0.001 | 20.87 (22.26) | 24.60 (38.84) | 27.54 (18.68) | 30.65 (19.15) | < 0.001 | 21.48 (22.38) | 23.19 (15.83) | 26.69 (16.59) | 31.73 (40.39) | < 0.001 | 21.84 (20.60) | 23.25 (15.71) | 27.58 (40.29) | 32.54 (20.98) | < 0.001 |
| AST, IU/L | 14,621 | 25.39 (17.80) | 24.26 (22.97) | 24.61 (18.88) | 25.43 (12.74) | 27.23 (15.11) | < 0.001 | 24.34 (19.65) | 24.81 (12.50) | 26.04 (21.98) | 26.39 (15.54) | < 0.001 | 24.50 (20.45) | 24.31 (16.61) | 25.39 (16.24) | 27.23 (17.58) | < 0.001 | 24.86 (19.58) | 24.00 (13.08) | 25.27 (19.75) | 27.90 (17.51) | < 0.001 |
| TBil, umol/L | 14,633 | 12.74 (5.16) | 12.70 (5.30) | 13.01 (5.40) | 12.71 (5.10) | 12.54 (4.79) | 0.15 | 13.22 (5.26) | 13.15 (5.36) | 12.78 (5.02) | 11.82 (4.86) | < 0.001 | 12.72 (5.25) | 12.87 (5.22) | 12.73 (5.30) | 12.65 (4.87) | 0.80 | 13.47 (5.47) | 13.03 (5.14) | 12.36 (4.85) | 11.86 (4.90) | < 0.001 |
| GGT, IU/L | 14,639 | 28.21 (39.76) | 19.73 (23.78) | 23.34 (23.67) | 28.81 (31.76) | 40.78 (62.89) | < 0.001 | 20.87 (28.32) | 25.75 (30.61) | 30.08 (40.94) | 36.31 (52.87) | < 0.001 | 21.47 (31.50) | 23.46 (24.23) | 28.90 (31.87) | 38.27 (58.63) | < 0.001 | 22.21 (29.44) | 23.96 (27.02) | 29.73 (32.49) | 39.68 (63.08) | < 0.001 |
| Serum K, mmol/L | 14,638 | 4.03 (0.33) | 4.00 (0.32) | 4.03 (0.33) | 4.04 (0.34) | 4.07 (0.34) | < 0.001 | 4.01 (0.34) | 4.03 (0.34) | 4.04 (0.32) | 4.06 (0.32) | < 0.001 | 4.01 (0.33) | 4.03 (0.33) | 4.04 (0.34) | 4.06 (0.33) | < 0.001 | 4.02 (0.34) | 4.02 (0.33) | 4.05 (0.32) | 4.06 (0.34) | < 0.001 |
| Serum Na, mmol/L | 14,639 | 139.13 (2.16) | 139.23 (2.16) | 139.26 (2.07) | 139.21 (2.08) | 138.83 (2.29) | < 0.001 | 139.14 (2.19) | 139.33 (2.23) | 139.19 (2.05) | 138.87 (2.14) | < 0.001 | 139.22 (2.24) | 139.26 (2.05) | 139.15 (2.16) | 138.90 (2.18) | < 0.001 | 139.17 (2.19) | 139.26 (2.10) | 139.16 (2.07) | 138.88 (2.27) | < 0.001 |
| Serum Fe, umol/L | 14,631 | 16.22 (6.54) | 15.68 (6.90) | 16.39 (6.81) | 16.37 (6.30) | 16.38 (6.12) | < 0.001 | 17.33 (7.28) | 16.61 (6.63) | 16.26 (6.17) | 14.65 (5.66) | < 0.001 | 16.00 (6.95) | 16.41 (6.72) | 16.13 (6.47) | 16.29 (6.04) | 0.06 | 17.21 (7.20) | 16.61 (6.58) | 15.88 (6.07) | 14.78 (5.78) | < 0.001 |
| WBC, *10^9/L | 14,627 | 6.78 (2.19) | 6.13 (1.81) | 6.65 (2.36) | 6.95 (2.21) | 7.35 (2.14) | < 0.001 | 6.29 (1.95) | 6.57 (2.45) | 6.84 (2.00) | 7.42 (2.17) | < 0.001 | 6.09 (1.87) | 6.58 (2.08) | 7.03 (2.23) | 7.35 (2.32) | < 0.001 | 6.28 (2.34) | 6.62 (2.18) | 6.94 (2.00) | 7.45 (2.01) | < 0.001 |
| PLT, *10^9/L | 14,626 | 251.13 (66.10) | 242.04 (62.14) | 251.31 (65.92) | 254.86 (66.94) | 255.81 (68.22) | < 0.001 | 247.52 (62.97) | 246.04 (64.22) | 251.26 (64.76) | 259.79 (71.34) | < 0.001 | 241.84 (61.92) | 251.14 (65.30) | 256.04 (68.23) | 254.96 (67.67) | < 0.001 | 246.55 (64.40) | 250.52 (64.12) | 253.34 (64.61) | 255.51 (71.84) | < 0.001 |
| Hemoglobin, g/L | 14,627 | 144.44 (14.69) | 139.98 (14.17) | 143.55 (14.57) | 145.81 (14.44) | 148.23 (14.33) | < 0.001 | 141.35 (13.63) | 145.05 (14.46) | 146.01 (14.66) | 145.45 (15.52) | < 0.001 | 139.34 (13.83) | 143.33 (14.32) | 145.26 (14.72) | 149.37 (14.08) | < 0.001 | 142.43 (14.20) | 144.52 (14.31) | 145.68 (15.05) | 145.64 (15.08) | < 0.001 |
The data was shown as mean (SD)
TyG index triglyceride glucose index, METS-IR metabolic score for Insulin resistance, TG triglyceride, HDL-C high-density lipoprotein-cholesterol, HOMA-IR homeostatic model assessment of insulin resistance, HbA1C glycosylated hemoglobin, FINS fasting serum insulin, FPG fasting plasma glucose, LDL-C low-density lipoprotein-cholesterol, TC cholesterol, Scr serum creatinine, BUN blood urea nitrogen, LDH lactate dehydrogenase, ALT alanine transaminase, AST aspartate transaminase, TBil total bilirubin, GGT gamma glutamyl transferase, K potassium, Na sodium, Fe iron, WBC white blood cells, PLT blood platelet
P values in bold meant significantly different (P < 0.05)