Table 5.
Threshold effect analysis of TyG index, METS-IR, TG/HDL-C and HOMA-IR on all-cause and cardiovascular mortality, NHANES 2001–2018
| TyG index | Adjusted HR (95% Cl), P-Value | METS-IR | Adjusted HR (95% Cl), P-Value | TG/HDL-C | Adjusted HR (95% Cl), P-Value | HOMA-IR | Adjusted HR (95% Cl), P-Value |
|---|---|---|---|---|---|---|---|
| All-cause mortality | |||||||
| Fitting by the standard linear model | 1.130 (1.039–1.230) 0.004 | Fitting by the standard linear model | 1.015 (1.008–1.022) < 0.001 | Fitting by the standard linear model | 1.003 (0.991–1.014) 0.630 | Fitting by the standard linear model | 1.016 (1.011–1.021) < 0.001 |
| Fitting by the two-piecewise linear model | Fitting by the two-piecewise linear model | Fitting by the two-piecewise linear model | Fitting by the two-piecewise linear model | ||||
| Inflection point | 8.61 | Inflection point | 41.33 | Inflection point | 1.98 | Inflection point | 2.49 |
| TyG index < 8.61 | 0.925 (0.678–1.262) 0.622 | METS-IR < 41.33 | 0.972 (0.950–0.997) 0.030 | TG/HDL-C < 1.98 | 0.879 (0.686–1.127) 0.310 | HOMA-IR < 2.49 | 0.982 (0.833–1.157) 0.826 |
| TyG index ≥ 8.61 | 1.257 (1.108–1.426) < 0.001 | METS-IR ≥ 41.33 | 1.019 (1.011–1.026) < 0.001 | TG/HDL-C ≥ 1.98 | 1.000 (0.989–1.012) 0.979 | HOMA-IR ≥ 2.49 | 1.015 (1.010–1.020) < 0.001 |
| P for Log-likelihood ratio | 0.005 | P for Log-likelihood ratio | < 0.001 | P for Log-likelihood ratio | 0.630 | P for Log-likelihood ratio | < 0.001 |
| Cardiovascular mortality | |||||||
| Fitting by the standard linear model | 0.959 (0.765–1.201) 0.713 | Fitting by the standard linear model | 1.018 (1.004–1.032) 0.012 | Fitting by the standard linear model | 0.996 (0.972–1.021) 0.748 | Fitting by the standard linear model | 1.008 (0.999–1.018) < 0.001 |
| Fitting by the two-piecewise linear model | Fitting by the two-piecewise linear model | Fitting by the two-piecewise linear model | Fitting by the two-piecewise linear model | ||||
| Inflection point | 8.61 | Inflection point | 41.33 | Inflection point | 1.98 | Inflection point | 2.49 |
| TyG index < 8.61 | 1.025 (0.521–2.016) 0.943 | METS-IR < 41.33 | 0.964 (0.915–1.015) 0.162 | TG/HDL-C < 1.98 | 0.953 (0.595–1.525) 0.839 | HOMA-IR < 2.49 | 0.964 (0.691–1.345) 0.830 |
| TyG index ≥ 8.61 | 1.042 (0.758–1.432) 0.801 | METS-IR ≥ 41.33 | 1.028 (1.014–1.043) < 0.001 | TG/HDL-C ≥ 1.98 | 0.995 (0.973–1.018) 0.687 | HOMA-IR ≥ 2.49 | 1.010 (1.002–1.018) < 0.001 |
| P for log-likelihood ratio | 0.706 | P for log-likelihood ratio | 0.022 | P for log-likelihood ratio | 0.735 | P for log-likelihood ratio | 0.124 |
All-cause mortality was adjusted for age, gender, race, BMI, PIR, education, drinking, smoking, CVD, Scr, SBP, BUN, hypertension
Cardiovascular mortality was adjusted for age, gender, race, BMI, PIR, education, drinking, smoking, HbA1C, FPG, Scr, ALT, SBP
TyG index triglyceride glucose index, METS-IR metabolic score for Insulin resistance, TG triglyceride, HDL-C high-density lipoprotein-cholesterol, HOMA-IR homeostatic model assessment of insulin resistance, BMI body mass index, PIR the ratio of family income to poverty, CVD cardiovascular disease, Scr serum creatinine, SBP systolic pressure, BUN blood urea nitrogen, HbA1C glycosylated hemoglobin, FPG fasting plasma glucose, ALT alanine transaminase, HR hazard ratio, CI confidence interval
P values in bold are < 0.05