Table 2.
Overview of primary and secondary study outcomes
| Overall | Restrictive fluid group | Liberal fluid group | Effect estimates with 95% CI | P value | |
|---|---|---|---|---|---|
| Number of participants | 196 | 92 | 104 | ||
| Death before discharge home by day 90 (n [%]) | 61 (31.1) | 20 (21.7) | 41 (39.4) | 0.50 (0.29 to 0.85)1 | 0.009 |
| Days free from ventilator use at 28 days (mean ± SD) | 18.6 ± 13.0 | 21.0 ± 11.8 | 16.5 ± 13.6 | 4.5 (0.9 to 8.1)2 | 0.015 |
| Days free from vasopressor use at 28 days (mean ± SD) | 17.42 (11.8) | 19.7 ± 10.4 | 15.4 ± 12.6 | 4.3 (1.0 to 7.5)2 | 0.010 |
| Days out of the ICU by day 28 (mean ± SD) | 18.1 ± 11.4 | 19.1 ± 10.9 | 17.2 ± 11.8 | 1.9 (-1.3 to 5.1)2 | 0.241 |
| Days out of the hospital by day 28 (mean ± SD) | 11.7 ± 11.2 | 13.3 ± 11.0 | 10.3 ± 11.3 | 2.9 (-0.2 to 6.1)2 | 0.067 |
| New intubation with invasive mechanical ventilation by 28 days (n [%]) | 30 (17.4) | 12 (14.8) | 18 (19.8) | 0.70 (0.3 to 1.7)3 | 0.427 |
| ARDS onset between day 1 and day 7 (n [%]) | 6 (3.1) | 1 (1.1) | 5 (4.9) | 0.22 (0.0 to 2.1)3 | 0.219 |
1Hazard ratio
2Mean difference
3Odds ratio