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. 2024 Jul 11;25:234. doi: 10.1186/s12859-024-05845-z

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Visualization of DARs identified for amiodarone and valproic acid within the Recon2.2 metabolic network. This visualization was performed with MetExploreViz while removing side compounds (S4 Table). DARs identified for amiodarone (7 µM, 24 h) are highlighted in panel A and DARs identified for valproic acid (5000 µM, 24 h) are highlighted in panel B, with more frequently active reactions in the exposed versus control condition colored in red and less frequently active reactions in green. Nodes represent reactions and metabolites and are connected if a metabolite is a product or a substrate of a reaction. The two figures are based on the same network layout; thus, each reaction and metabolite is located at the same coordinates, allowing visual comparison. Interactive visualizations can be accessed through the following links: https://metexplore.toulouse.inrae.fr/userFiles/metExploreViz/index.html?dir=/5b6c886c4916c1de9e6c16a776cc6d64/networkSaved_1726726315 and https://metexplore.toulouse.inrae.fr/userFiles/metExploreViz/index.html?dir=/5b6c886c4916c1de9e6c16a776cc6d64/networkSaved_1522683843. The same visualization, with DARs colored according to their cluster’s group rather than their activity status, is also provided as supplementary material (S4 Fig)