#	Searches Ovid MEDLINE(R) All
1	exp sepsis/ or exp bacteremia/ or exp fungemia/ or exp shock, septic/
2	(sepsis or septic* or bacter?emi* or candidemia* or endotox?emi* or fungemi* or pyemia* or pyohemia* or pyaemia*).ti,ab,kw,kf.
3	(Blood* adj3 (infect* or poison*)).ti,ab,kw,kf.
4	exp Meningitis, Bacterial/
5	(meningiti* adj2 bacterial*).ti,ab,kw,kf.
6	(Meningiti* adj2 (Escherichia* coli or Haemophilu* or Listeria* or Meningococca* or penicillin‐resistant or pneumococca*)).ti,ab,kw,kf.
7	exp Streptococcal Infections/ or exp Streptococcus/
8	streptococc*.ti,ab,kw,kf.
9	Klebsiella/ or Enterobacter/ or exp Pseudomonas/
10	(Klebsiella* or Enterobacter* or Pseudomona*).ti,ab,kw,kf.
11	or/1‐10 [Sepsis and associated]
12	exp anti‐bacterial agents/
13	Anti‐Infective Agents/ [Not exploding; MeSH says to prefer specifics‐‐ which we have done; subterms are irrelevant per clinician review]
14	(antibiotic* or antibacterial* or anti‐bacteria* or antiinfecti* or anti‐infecti* or bactericid*).ti,ab,kw,kf.
15	exp Quinolines/
16	(quinolone? or quinoline?).ti,ab,kw,kf.
17	exp Sulfonamides/
18	sulfonamide*.ti,ab,kw,kf.
19	exp Penicillins/ or exp beta‐Lactams/ or beta‐Lactamase Inhibitors/
20	(penicillin* or ampicillin* or Pentrexyl or Polycillin* or Ukapen or Amcill or Amcill or omnipen or ((beta Lactamase* or beta‐Lactamase) adj2 (inhibitor* or antagonist?))).ti,ab,kw,kf.
21	(Benzylpenicillin or Coliriocilina or Crystapen or "Or‐pen" or Parcillin or Pekamin or Pengesod or Penibiot or Penilevel or Peniroger or Pfizerpen or Sodiopen or Sodipen or Unicilina or Ursopen or Van‐Pen‐G or Benpen or Floxacillin* or Fluorochloroxacillin* or Flucloxacillin* or beta lactamase? or beta‐lactamase? or Carbapenem* or Cephalosporin* or Cefotaxim* or Cephotaxim* or Cefotaxim or Biosint or Cefradil or Taporin or Fotexina or Benaxima or Claforan or Primafen or Klaforan or Meropenem* or Merrem or ronem or penem or (Piperacillin adj2 Tazobactam) or Tazocin or Tazocillin or Zosyn or Tazocel or Monobactam*).ti,ab,kw,kf. [Selected pencillins/beta lactamase]
22	Aminoglycosides/
23	Aminoglycoside*.ti,ab,kw,kf.
24	Gentamicins/
25	(Gentamycin* or Garamycin or Gentacycol or Gentavet or Genticin or G‐Myticin or G Myticin or GMyticin or Gentamicin).ti,ab,kw,kf.
26	Vancomycin/
27	(Vancomycin* or AB‐Vancomycin* or Vanco Azupharma or Diatracin or VANCO‐cell or Vanco‐saar or Vancocin or Vancocine or Vancomicin*).ti,ab,kw,kf.
28	Metronidazole/
29	Metronidazol*.ti,ab,kw,kf.
30	Teicoplanin/ [glycopeptide]
31	(Teichomycin* or targocid?).ti,ab,kw,kf.
32	Glycopeptides/ [Proteins which contain carbohydrate groups attached covalently to the polypeptide chain. The protein moiety is the predominant group with the carbohydrate making up only a small percentage of the total weight.]
33	Glycopeptid*.ti,ab,kw,kf.
34	or/12‐33 [Antibiotics and related agents]
35	exp Infant, Newborn/ or Intensive Care, Neonatal/ or Intensive Care Units, Neonatal/ or Gestational Age/
36	(babe or babes or baby* or babies or gestational age? or infant? or infantile or infancy or low birth weight or low birthweight or neonat* or neo‐nat* or newborn* or new born? or newly born or premature or pre‐mature or pre‐matures or prematures or prematurity or pre‐maturity or preterm or preterms or pre term? or preemie or preemies or premies or premie or VLBW or VLBWI or VLBW‐I or VLBWs or LBW or LBWI or LBWs or ELBW or ELBWI or ELBWs or NICU or NICUs).ti,ab,kw,kf.
37	or/35‐36 [Filter: Neonatal Population 04‐2022‐MEDLINE]
38	randomized controlled trial.pt.
39	controlled clinical trial.pt.
40	randomized.ab.
41	placebo.ab.
42	clinical trials as topic.sh.
43	randomly.ab.
44	trial.ti.
45	or/38‐44 [Cochrane HSSS‐SP Maximizing RCT Filter]
46	(quasirandom* or quasi‐random* or random*).ti,ab,kw,kf.
47	(control* adj2 (group? or trial? or study)).ti,ab,kw,kf.
48	or/46‐47 [Additional terms to increase sensitivity]
49	exp animals/ not humans/
50	(or/45,48) not 49 [RCT Filter]
51	meta‐analysis/ or "systematic review"/ or network meta‐analysis/ [/ finds same as.pt. syntax]
52	((systematic* adj3 (review* or overview*)) or (methodologic* adj3 (review* or overview*))).ti,ab,kf,kw.
53	((integrative adj3 (review* or overview*)) or (collaborative adj3 (review* or overview*)) or (pool* adj3 analy*)).ti,ab,kf,kw.
54	(data synthes* or data extraction* or data abstraction*).ti,ab,kf,kw.
55	(hand search* or handsearch*).ti,ab,kf,kw.
56	(mantel haenszel or peto or der simonian or dersimonian or fixed effect* or latin square*).ti,ab,kf,kw.
57	meta‐analysis as topic/ or network meta‐analysis/
58	(meta analy* or metanaly* or meta regression* or metaregression*).ti,ab,kf,kw.
59	(medline or cochrane or pubmed or medlars or embase or cinahl).ab.
60	(cochrane or systematic review?).jw.
61	or/51‐60 [SR filter‐Medline; based on CADTH https://searchfilters.cadth.ca]
62	11 and 34 and 37 and 50 [Sepsis AND Antibiotics AND Neonates AND RCT]
63	11 and 34 and 37 and 61 and ("2022" or "2023").yr. [SR Results]
64	or/62‐63 [All results Medline]