FIG. 4.

VSV-infected PKR^−/− mice show high lung titers compared with control mice. IFN-α-treated and untreated PKR^−/− and control mice were infected i.n. with 5 × 10⁴ PFU and sacrificed for their organs on day 4 p.i. Titers in blood, spleen, kidney, liver, brain, and lung tissues were determined, and only brain and lung tissue showed any detectable virus. Although brain tissue titers from PKR^−/− and control mice were similar (<10⁵ PFU/g), lung titers in PKR^−/− animals were 2 to 3 logs higher than those seen in control mice. IFN-α/β treatment of PKR^−/− mice did not reduce virus titers and perhaps even resulted in a slight increase in both brain and lung tissues. Virus titers are expressed as PFU per gram of tissue. Data represent means ± standard errors of the means of triplicate experiments.