TABLE 1.
PKR−/− or PKR+/+ mice infected i.n. with various doses of VSVa
| Genetic background | Strain | i.n. dose (PFU) | No. of mice surviving at day 5/total no. of mice |
|---|---|---|---|
| PKR+/+ | BALB/c | 5 × 104 | 5/5 |
| CD1 | 5 × 104 | 5/5 | |
| BALB/c × 129 | 5 × 104 | 5/5 | |
| PKR−/− | BALB/c × 129 | 5 × 104 | 0/5 |
| 5 × 103 | 0/4 | ||
| 5 × 102 | 0/3 | ||
| 5 × 101 | 0/3 |
a
PKR−/− and PKR+/+ control mice were infected i.n. with various doses, and their survival was monitored over time. All PKR−/− mice succumbed to the infection between days 2 and 5 depending on the dose, while control mice remained alive beyond this point.