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AIF MST Screen. (A) AIF MST screening results from the focused 96-fragment library. Red line indicates three standard deviations from the average DMSO response amplitude. (B) MST titration curves and affinities for the top fragment ligands. Response amplitudes were exported and fit for one-site binding in GraphPad Prism 9. Values in parentheses are fitting errors. (C) The top MST candidates reveal an enrichment of benzothiazolamine scaffolds.
